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Cialis generika in deutschland zugelassen. has so far been the most active in taking new patients with the drug, after North Dakota and South Dakota, the report said. However, in a study of the drug in United Kingdom, Dr. Paul Wilson, senior lecturer in the department of infectious disease epidemiology and at the University of Nottingham in England, found that, general, new patients were about a fifth less likely to die in the first two months of treatment than the same patients with standard therapy. Newsletter Sign Up Continue reading the main story Please verify you're not best drugstore shampoo for hair loss a robot by clicking the box. Invalid email address. Please re-enter. You must select a newsletter to subscribe to. Sign Up You will receive emails containing news content, updates and promotions from The New York Times. You may opt-out at any time. You agree to receive occasional updates and special offers for The New York Times's products and services. Thank you for subscribing. An error has occurred. Please try again later. View all New York Times newsletters. He said there was evidence that patients might have gained resistance. "It seems that there are some patients who resistant now," he said. "That needs to be studied." In the United States, which has several pharmaceutical companies manufacturing generic generics of high-priced brand-name drugs, the situation can get more complicated. The generic version of injectable drug Gleevec had to be developed in three successive years, due to a combination of factors, the makers noted. One was fact that it designed to prevent a heart attack but could cause serious inflammation and kidney failure if used for treatment of pneumonia. Another was that the medicine could give people cancer, making it impossible to make drugs for those other cancers. The drug has long been off-patent — with the exception of Gleevec's patents. Under United States law, any company making generic versions of drugs is expected to pay a royalty the patent holder for each dose of the drug used. Advertisement Continue reading the main story The Food and Drug Administration, which licenses the medications to be sold under brand names in the United States, said Gleevec was the first generic of Gleevec that had been approved. The agency approved a generic of the same medication to allow it be sold in Canada and other countries. Dr. Wilson and others say it is not surprising that drug makers are trying to come up with new ways to bring prices down and that some are being successful. "If you look at what's happening in the world, it's all a matter of competition and price," Dr. Wilson said. "When you have a monopoly, if someone else offers an alternative product, people go for it." But he also said the fact that a generic is cheaper does not mean that a company should profit for selling it even if is less effective. "If they pay for that drug only to make a profit on that drug, they are not going to be a model for future generics and competition," he said. In the United States, generics have been sold as "bundles" of drugs, or drug combinations that could be used without any individual drugs. "The best example is Glivec," said Dr. Wilson, "though you have to buy Gleevec and Vioxx, too." The most recent drugs to come into the market after Gleevec were Vioxx and Humira, generics of the same drug. But a generic may not be available forever. Dr. Wilson said he believed there were many companies who already developing branded biosimilars that are likely to be less costly than brand-name copies. The question many companies are grappling with is whether they have the intellectual property needed to sue if someone is trying to patent or copyright a generic molecule. company that is not at risk of losing a patent might be sued for infringement, though whether the plaintiff would win is hard to predict, he said. As part of its effort to bring new drugs market, the FDA has recently asked companies interested in selling biosimilars to register an indication for the generic product, so that it can be marketed across various countries. "We believe that by making an indication for the generic you give product to the regulatory authorities who can assess"
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