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Generic brands of lorazepam that are available and in which the patient does not understand risks and benefits associated with the medication. In other studies, presence of the drug in a patient's home or workplace has been reported to increase the likelihood of drug abuse, thus increasing the possibility of a lethal overdose[3]. recent study from the University of Pennsylvania[4] showed that nearly 30 percent of all drug-related deaths in the workplace involved lorazepam. The use of lorazepam for its sedative effect and short-acting anti-anxiety effects in treating anxiety patients with advanced cancer has been a popular alternative for several years. Because of the lack pharmacokinetic information on its drug-to-ingestion and delivery profiles, it was difficult to assess the potential risks of lorazepam and its associated side-effects. A retrospective survey of lorazepam-treated patients with acute myeloid leukemia who had been prescribed the medication for 12 months revealed that more than 80 percent of them reported adverse drug events and a similar percentage had experienced serious side effects, and a larger proportion of them reported serious adverse events after treatment[5]. A recent study that involved the review of 2,914 outpatient and inpatient lorazepam prescriptions analyzed the adverse event records for first 6 years of use found that lorazepam was associated with an increased rate of reported adverse events, such as liver cirrhosis, hepatocellular carcinoma, and renal failure[6]. This case is an example of the potential harms associated with lorazepam use and how can increase the risk of death by overdose. Toxicity and Metabolism At its base, lorazepam is a benzodiazepine, which class of medications used for treatment anxiety, panic disorders, and seizures. These medications bind to benzodiazepine receptors in the brain, and they also interact with other brain chemicals to produce the effects of benzodiazepines. Lorazepam binds to the benzodiazepine receptors and is metabolized by the liver into its active form, lorazepam, which is a powerful tranquilizer. Once the drug leaves body, however, it undergoes the Gabapentin generic cost metabolism of its active form into lorazepam sulfate, which can produce respiratory depression, muscle rigidity, and cardiac neurologic effects. Because lorazepam's chemical structure is very similar to that of the benzodiazepine, lorazepam has many of the same side effects as these drugs, including sedation and sedative-hypnotic-anxiolytic drug interactions[7]. Lorazepam is absorbed through the skin and reaches brain within about 4 to 7 hours of oral administration, and lorazepam is excreted within 8 to 12 hours. Ingestion of too much lorazepam has resulted in fatal cases of lorazepam toxicity and has even resulted in fatal liver failure certain individuals, although these deaths have been rare in general medical practice[8]. There is no direct evidence to indicate that lorazepam is directly toxic from oral or inhalant exposure. However, some lorazepam abusers have reported adverse effects with lorazepam inhalation, as reported in the literature[9,10]. Lorazepam can have an effect on metabolism if ingested in large quantities. the United online pharmacy adderall with prescription States, no formal recommendations exist regarding the level of lorazepam required to cause toxic effects in patients who swallow large amounts of the substance. However, Lorazepam was removed from the market in many parts of the world, such as Russia, when it had a higher potential to cause kidney toxicity. The use of lorazepam at recommended amounts, particularly those in conjunction with alcohol, has been associated adverse effects in a small number of patients with hepatic impairment associated alcohol abuse[11,12]. Treatment Although there are no specific treatment guidelines for lorazepam withdrawal syndrome, it is typically treated for its associated anxiety symptoms. It is usually best to discontinue lorazepam use in the acute phase and then allow the patient to continue with their normal schedule. Because lorazepam is a long-acting drug, in terms of the effects drug, it is important to continue taking lorazepam even when symptoms of withdrawal may be less prominent or when the person may be unable to tolerate or cope with treatment and treatment-related side effects. In the absence of other treatment options, the best solution is to try manage with medications, such as benzodiazepines. References 1. National Institutes of Health. Clinical guidance for the management of benzodiazepine withdrawal syndrome.
