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Generic losartan potassium -citrate in healthy volunteers without a history of renal or hepatic disease INTRODUCTION The most common form of treatment for hyperkalemia is administration of potassium-citrate. In healthy volunteers, the pharmacokinetics of potassium citrate has been well established, whereas its pharmacodynamics has not been investigated (1). A major disadvantage of potassium citrate is that its use associated with unwanted side effects, including myalgia, vomiting, and nausea. To prevent such side effects, potassium citrate may be limited to intravenous administration. The aim of our study was to the pharmacokinetics and pharmacodynamics of potassium citrate in healthy volunteers without a history of renal or hepatic disease receiving a single dose of the drug. METHODS AND RESULTS We enrolled 21 healthy volunteers, aged between 27 and 57 years old (mean 46 years), who were willing to take part in the study and were able to obtain informed consent before the beginning of study (2). All the subjects had no history of renal or hepatic disease. The volunteers were assigned randomly to receive either 250 mg/d (n = 9) or 500 mg/d (n = 10) potassium citrate. We excluded three subjects who were intoxicated in the hospital. At baseline, the subjects were interviewed regarding use of other drugs (except for the use of alcohol) during 10 months before the study. volunteers were also instructed to refrain buy generic zoloft canada from Terbinafine hydrochloride cream dosage the use of any drugs for the next 3 d until day of the study. volunteers were asked to consume a potassium-citrate-supplemented meal at least 1 h before the study. At baseline and after the study in a randomized cross-over design, the volunteers ingested either 250 or 500 mg of potassium citrate. The pharmacokinetics of drug were measured through a double-antibody and single-antibody screen, in a single day (3, 4). At baseline and the end of study, serum potassium levels the healthy volunteers were measured with the use of a hemolyzer (4-I) and the intraperitoneal extraperitoneal Generic duloxetine europe radioactivity was measured with a radioimmunoassay. The intraperitoneal radioactivity was measured according to the manufacturer´s protocol (AQ Diagnostics, West Caldwell, NJ) and the extraperitoneal radioactivity was determined by radioimmunoassay (5-I). The level of intraperitoneal potassium was measured by a radioimmunoassay (AQ Diagnostics). The concentration of extracorporeal (EC) potassium was measured with the use of radioimmunoassay (5-I). The serum potassium levels of volunteers were also determined through a hemolyzer with the use of an automated multiplex assay (4-I), in a single day (6, 7). The concentration of K(+)-citrate was measured with the use of an in vitro assay (6, 7). K(+)-citrate was identified by using chromatographic chromatography (15, 21). In brief, the compound Tamsulosin er 0.4 mg capsule K(+)-citrate was generated by the simultaneous binding of substrate for the citrate 1,1-diol form of K.
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Ciprofloxacin tinidazole tablet or oral solution Interventional Phase 2 Peking University Other Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Prevention Incidence of treatment related adverse events Maximum plasma buy zoloft online with prescription concentration of ciprofloxacin after single dose administration Clinical response to 1 or 2 dose of Ciprofloxacin in the laboratory (and 3 more...) 200 All 18 Years to 60 (Adult) NCT03692310 PekingU-2016-01 December 1, 2016 February 2019 January 22, 2017 July 9, 2018 Peking University Hospital Beijing, China 16 NCT01274850 Completed Has Results Sustained Effectiveness of a New Combination Multicenter Multitargeted Oral Therapy to Treat Cancers Drug: ciprofloxacin Drug: indomethacin Drug: metronidazole (and 3 more...) Interventional Phase 2 Shanghai Jiao Tong University Other Allocation: Randomized Intervention Model: Single Group Assignment Primary Purpose: Treatment Incidence of Serious Adverse Events after a Single Dose Treatment of 1 mg or More Ciprofloxacin 1,000 Greater Incidence of Serious Adverse Events after an Oral Dose of 1 to 10 mg Ciprofloxacin 100 or Greater Incidence of Serious Adverse Events after an buy cheap zoloft online Oral Dose of 10 to 40 mg zoloft bestellen ohne rezept Ciprofloxacin 120 or Greater (and 5 more...) 60 All 18 Years and older (Adult, Adult) NCT01274850 CIPRO-2013-003 January 2014 August 2015 February 19, 2013 Shanghai Jiao Tong University School of Medicine (SJTUMS) Shanghai, China 17 NCT01985094 Completed Has Results Efficacy and Safety of Ciprofloxacin ( + Cefixime ) In Combination With Aztreonam a Population Advanced Solid Tumors Drug: Ciprofloxacin Drug: Aztreonam Drug: Cefixime Interventional Phase 3 University of Texas MD Anderson Cancer Center Other Intervention Model: Single Group Assignment Primary Purpose: Treatment Toxicity Incidence of Adverse Events as Reported in the Pregnancy Registry Overall Survival as Reported in the Pregnancy Registry (and 6 more...) 15 All 18 Years and older (Adult, Adult) NCT01985094 2012-0018 October 2012 November drugstore eye primer uk 2015 September 5, 12, Department of Surgery, Radiology, and Medical Oncology, University of Texas MD Anderson Cancer Center Houston, Texas, United States 18 NCT03687441 Recruiting Ciprofloxacin and Etoposide in Combination With Aztreonam and Dacarbazine to Treat Patients With Malignant Breast Tumors Cancer Drug: Cipro and Etoposide Drug: Cipro and Dacarbazine Drug: Dacarbazine Interventional Phase 2 University of Texas MD Anderson Cancer Center Celgene Other/Industry Allocation: Non-Randomized Intervention Model: Parallel Assignment Primary Purpose: Treatment Incidence of Treatment-Emergent Adverse Events, Serious and Events with Ciprofloxacin Etoposide in Combination Aztreonam, Acetylsalicylic Acid, Dacarbazine and/or and Etoposide in Combination with Aztreonam, Acetylsalicylic Acid, Dacarbazine and/or Number of Participants With Adverse Events Clinical Response Rate (CRR) to Treatment with Ciprofloxacin and Etoposide 100 All 18 Years and older (Adult, Adult) NCT03687441 2012-0017 December 2016 August 2018 June 10, 14, Department of Surgery, MD Anderson Cancer Center 19 NCT01985091 Completed Has Results Efficacy and Safety of Ciprofloxacin in Combination With Aztreonam and Dacarbazine in Solid Tumors Drug: Ciprofloxacin
